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Search: WFRF:(Bønnelykke Klaus) > Jaddoe' Vincent W. V. > (2019) > Variants in the fet...

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Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration.

Liu, Xueping (author)
Danish Serum Institute, Copenhagen
Helenius, Dorte (author)
Skotte, Line (author)
show more...
Beaumont, Robin N (author)
Wielscher, Matthias (author)
Geller, Frank (author)
Juodakis, Julius (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Mahajan, Anubha (author)
Bradfield, Jonathan P (author)
Lin, Frederick T J (author)
Vogelezang, Suzanne (author)
Bustamante, Mariona (author)
Ahluwalia, Tarunveer S (author)
Pitkänen, Niina (author)
Wang, Carol A (author)
Bacelis, Jonas (author)
Borges, Maria C (author)
Zhang, Ge (author)
Bedell, Bruce A (author)
Rossi, Robert M (author)
Skogstrand, Kristin (author)
Peng, Shouneng (author)
Thompson, Wesley K (author)
Appadurai, Vivek (author)
Lawlor, Debbie A (author)
Kalliala, Ilkka (author)
Power, Christine (author)
McCarthy, Mark I (author)
Boyd, Heather A (author)
Marazita, Mary L (author)
Hakonarson, Hakon (author)
Hayes, M Geoffrey (author)
Scholtens, Denise M (author)
Rivadeneira, Fernando (author)
Jaddoe, Vincent W V (author)
Vinding, Rebecca K (author)
Bisgaard, Hans (author)
Knight, Bridget A (author)
Pahkala, Katja (author)
Raitakari, Olli (author)
Helgeland, Øyvind (author)
Johansson, Stefan (author)
Njølstad, Pål R (author)
Fadista, Joao (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Danish Serum Institute, Copenhagen
Schork, Andrew J (author)
Nudel, Ron (author)
Miller, Daniel E (author)
Chen, Xiaoting (author)
Weirauch, Matthew T (author)
Mortensen, Preben Bo (author)
Børglum, Anders D (author)
Nordentoft, Merete (author)
Mors, Ole (author)
Hao, Ke (author)
Ryckman, Kelli K (author)
Hougaard, David M (author)
Kottyan, Leah C (author)
Pennell, Craig E (author)
Lyytikainen, Leo-Pekka (author)
Bønnelykke, Klaus (author)
Vrijheid, Martine (author)
Felix, Janine F (author)
Lowe, William L (author)
Grant, Struan F A (author)
Hyppönen, Elina (author)
Jacobsson, Bo, 1960 (author)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Jarvelin, Marjo-Riitta (author)
Muglia, Louis J (author)
Murray, Jeffrey C (author)
Freathy, Rachel M (author)
Werge, Thomas M (author)
Melbye, Mads (author)
Buil, Alfonso (author)
Feenstra, Bjarke (author)
Danish Serum Institute, Copenhagen
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 (creator_code:org_t)
et al 
2019-09-02
2019
English.
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm birth in 84,689 infants. One locus on chromosome 2q13 is associated with gestational duration; the association is replicated in 9,291 additional infants (combined P = 3.96 × 10-14). Analysis of 15,588 mother-child pairs shows that the association is driven by fetal rather than maternal genotype. Functional experiments show that the lead SNP, rs7594852, alters the binding of the HIC1 transcriptional repressor. Genes at the locus include several interleukin 1 family members with roles in pro-inflammatory pathways that are central to the process of parturition. Further understanding of the underlying mechanisms will be of great public health importance, since giving birth either before or after the window of term gestation is associated with increased morbidity and mortality.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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By the author/editor
Liu, Xueping
Helenius, Dorte
Skotte, Line
Beaumont, Robin ...
Wielscher, Matth ...
Geller, Frank
show more...
Juodakis, Julius
Mahajan, Anubha
Bradfield, Jonat ...
Lin, Frederick T ...
Vogelezang, Suza ...
Bustamante, Mari ...
Ahluwalia, Tarun ...
Pitkänen, Niina
Wang, Carol A
Bacelis, Jonas
Borges, Maria C
Zhang, Ge
Bedell, Bruce A
Rossi, Robert M
Skogstrand, Kris ...
Peng, Shouneng
Thompson, Wesley ...
Appadurai, Vivek
Lawlor, Debbie A
Kalliala, Ilkka
Power, Christine
McCarthy, Mark I
Boyd, Heather A
Marazita, Mary L
Hakonarson, Hako ...
Hayes, M Geoffre ...
Scholtens, Denis ...
Rivadeneira, Fer ...
Jaddoe, Vincent ...
Vinding, Rebecca ...
Bisgaard, Hans
Knight, Bridget ...
Pahkala, Katja
Raitakari, Olli
Helgeland, Øyvin ...
Johansson, Stefa ...
Njølstad, Pål R
Fadista, Joao
Schork, Andrew J
Nudel, Ron
Miller, Daniel E
Chen, Xiaoting
Weirauch, Matthe ...
Mortensen, Prebe ...
Børglum, Anders ...
Nordentoft, Mere ...
Mors, Ole
Hao, Ke
Ryckman, Kelli K
Hougaard, David ...
Kottyan, Leah C
Pennell, Craig E
Lyytikainen, Leo ...
Bønnelykke, Klau ...
Vrijheid, Martin ...
Felix, Janine F
Lowe, William L
Grant, Struan F ...
Hyppönen, Elina
Jacobsson, Bo, 1 ...
Jarvelin, Marjo- ...
Muglia, Louis J
Murray, Jeffrey ...
Freathy, Rachel ...
Werge, Thomas M
Melbye, Mads
Buil, Alfonso
Feenstra, Bjarke
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Obstetrics Gynae ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
Articles in the publication
Nature communica ...
By the university
University of Gothenburg
Lund University

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